Differential regulation of IgG1 and IgE synthesis by interleukin 4.

Differential regulation of IgG1 and IgE synthesis by interleukin 4

IL-4/B cell stimulatory factor-1 is a T cell-derived lymphokine that has been shown to enhance IgG1 and IgE and to suppress IgG3 and IgG2b secretion by B cells stimulated with bacterial LPS. We show here that the stimulation of IgG1 and IgE secretion in response to rIL-4 is differentially regulated. The dose-response curve for IgG1 production is bimodal with peaks at 100 and 10,000 U/ml. IgE pr...

DIFFERENTIAL REGULATION OF IgGI AND IgE SYNTHESIS BY INTERLEUKIN

Interleukin 4 (IL-4)/B cell stimulatory factor 1 is a T cell-derived lymphokine that has effects on virtually all cells of hematopoietic origin. In particular, it strikingly enhances the secretion of IgGI and IgE in vitro and of IgE in vivo (1-10). IL-4 acts on cells that lack surface IgG to cause IgG1 production (1, 11), strongly suggesting that it promotes Ig class switching rather than the s...

Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice1

BACKGROUND The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation. METHODS IL-33 was administered to naïve wild-type (WT), nude and ST2(-/-) ,...

Association of Interleukin-4 and IgE Levels with LDL Oxidation in Atherosclerosis

Background: Atherosclerosis is an inflammatory and multifactorial disease, with a high prevalence rate in Pakistan. Objective: To find a relation between serum IL-4 and IgE levels with oxidized LDL in atherosclerosis. Methods: In this observational, cross sectional study 99 male patients, between forty and sixty years of age, with a history of ischemic heart disease (IHD) and established athero...

Stimulation of the B Cell CTLA-4 Receptor Inhibition of IgG1 and IgE Production by